Anti-CD3 Mouse mAb [09C51]

Protein G affinity purification

T-cell receptor CD3 complex

CD3 (T-cell surface glycoprotein CD3 complex) belongs to immunoglobulin superfamily and serves as the core transducer for T-cell receptor signaling. Assembled from γ, δ, ε and ζ subunits, CD3 is restrictively expressed on T-cell lineage and forms TCR-CD3 complex with T-cell receptor. Upon TCR recognition of antigen-MHC complex, intracellular ITAM motifs of CD3 become phosphorylated and relay downstream activation signals to trigger T-cell proliferation, cytokine secretion and cytotoxic effector functions. CD3 is a universal marker for all mature T lymphocytes to discriminate T-cells from other immune populations.

Cell membrane