Anti-FOXP3 Mouse mAb [69H47]

Protein A affinity purification

Fork-head box P3

FOXP3 (Forkhead Box Protein P3) is a specific member of the forkhead box transcription factor family, specifically expressed in human regulatory T cells (Treg). It plays a core role in regulating immune homeostasis, maintaining immune tolerance and inhibiting inflammatory responses. As a key transcription factor for the development and functional maturation of Treg cells, FOXP3 regulates the expression of multiple immune-related genes, inhibits the excessive activation of effector T cells, reduces abnormal immune responses and avoids autoimmune damage. Downregulated expression or functional defects of FOXP3 lead to Treg cell dysfunction and disrupted immune tolerance, causing autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis, and facilitating tumor immune escape and tumor proliferation and metastasis.

Nucleus