Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-phospho p44/42 MAPK (ERK1/2) (Thr202/Tyr204) Mouse mAb [25A91]
抗phospho p44/42 MAPK (ERK1/2) (Thr202/Tyr204)小鼠单克隆抗体 [25A91]
Cat. No.
A32065
Clone No. 25A91
Synonymsphospho p44/42 MAPK (ERK1/2) (Thr202/Tyr204), p-ERK1/2(Thr202/Tyr204), ERK1/2, extracellular signal-regulated kinase 1/2, MAPK1, MAPK3
详细信息 Product Information
Buffer
50% Glycerol, 0.5% BSA and 0.02% preservative in PBS (pH 7.2-7.4)
Purification
Antigen-affinity-purified
Concentration
Please check the information on the tube.
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
44/42 kDa
Observed MW
44/42 kDa
Modification
Phospho
Clonality
Monoclonal
Clone No.
25A91
抗原与靶点信息 Antigen & Target Information
Gene Name
MAPK3, MAPK1
Protein Name
phospho p44/42 MAPK (ERK1/2) (Thr202/Tyr204)
Background
Phospho-ERK1/2 (Thr202/Tyr204) is the hallmark modification for full activation of ERK1/2 kinases. The conserved dual phosphorylation sites Thr202/Tyr204 are specifically modified by upstream MEK kinases. Dual phosphorylation at these residues completely activates ERK1/2 kinase activity, promotes nuclear translocation and downstream signaling cascades, and mediates multiple biological effects including cell proliferation, inflammatory activation, metabolic reprogramming and malignant transformation. The phosphorylation level of Thr202/Tyr204 directly reflects the activation status of the MAPK/ERK pathway, and its aberrant elevation is a typical pathological feature of tumors, chronic inflammation, fibrosis and proliferative diseases.
Localization
Nucleus
Research Area
细胞生物学
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:500
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
相关产品 Related Products
Anti-IL-1β Rabbit mAb [99F42]
WBIPIFELISA
Anti-Polycomb Protein SUZ12 Rabbit mAb [36G88]
WBIHCIPIFELISA
价格与规格
该产品暂未录入规格价格，请联系我们获取报价与现货情况。