Anti-ε-Tubulin Mouse mAb [21H59]

Antigen-affinity-purified

Tubulin epsilon

Tubulin belongs to the tubulin superfamily and governs centriole assembly, centrosome maturation and cell‑cycle homeostasis. ε‑Tubulin specifically localizes to centrioles and contributes to the formation of mother‑centriole appendages, acting as an essential molecule for centriole duplication and assembly of functional mature centrosomes. Loss‑of‑function of ε‑Tubulin directly induces centriole morphological defects and aberrant centrosome copy numbers, which disrupt spindle organization, cause chromosome mis‑segregation and drive genomic instability. Its abundance is tightly cell‑cycle‑regulated and markedly elevated in highly proliferative cells. ε‑Tubulin does not participate in cytoplasmic microtubule cytoskeleton and acts specifically within centriole complexes. It is widely used in mechanistic researches of centriole biology, centrosome duplication, cell‑cycle control, genome stability and oncogenesis.

Cytoplasm