Anti-CD20 Mouse mAb [18E92]

Protein A affinity purification

B-lymphocyte antigen CD20

CD20 (B-lymphocyte surface antigen CD20, MS4A1) is a MS4A-family transmembrane protein that modulates B-lymphocyte activation and proliferation. CD20 is expressed from pre-B cell to mature B-cell stages and down-regulated upon plasma cell differentiation. Located on plasma membrane, CD20 modulates calcium flux and participates in B-cell receptor signaling network to shape B-cell activation and cell-cycle progression. Absent from hematopoietic stem cells, CD20 targeting depletes mature B-cells while sparing B-cell progenitors. CD20 represents a well-validated therapeutic target for B-cell lymphoma and autoimmune diseases. It is also widely used as biomarker for flow cytometry and IHC in B-cell neoplasm classification and B-cell status evaluation in autoimmune disorders.

Cell membrane