Anti-Aurora A Mouse mAb [97A96]

Affinity-purified

Aurora kinase-A

Full length

Aurora A is an essential isoform of the Aurora serine/threonine kinase family encoded by the AURKA gene, which serves as a master regulatory kinase for G2/M phase transition during the cell cycle. Localized at centrosomes and spindle poles and highly activated in prophase, Aurora A dominates centrosome maturation, spindle microtubule assembly, chromosome polarity establishment and G2/M phase transition, precisely controlling mitotic initiation and progression. Abnormal activation and overexpression of Aurora A induce centrosome amplification, spindle disorder and cell cycle dysregulation, promote unlimited proliferation and malignant transformation of tumor cells, and are frequently upregulated in various malignancies, making it a core target for tumor proliferation research and targeted drug development. Anti-Aurora A Rabbit mAb [97B07] is a rabbit specifically recognizing endogenous Aurora A, compatible with multiple immunological assays and suitable for cell cycle, tumorigenesis and targeted mechanism research.

Cytoplasm