Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-CHK2 Mouse mAb [32G17]
抗CHK2小鼠单克隆抗体 [32G17]
Cat. No.
A33028
Clone No. 32G17
SynonymsCHK2, CDS1, LFS2, RAD53, hCds1, HuCds1, PP1425
详细信息 Product Information
Buffer
0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
1 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
61 kDa
Clonality
Monoclonal
Clone No.
32G17
Isotype
IgG
抗原与靶点信息 Antigen & Target Information
Gene Name
CHEK2
Protein Name
Checkpoint kinase-2
Domain
Full length
Background
Chk2 (Checkpoint kinase 2) is a serine-threonine kinase mediating DNA-damage response and cell-cycle-checkpoint activation. Upon DNA double-strand break, ATM kinase phosphorylates and activates Chk2. Activated Chk2 phosphorylates downstream substrates such as Cdc25C and p53 to arrest cell-cycle progression and provide time window for DNA repair. Chk2 triggers G1/S and G2/M checkpoint responses, leading to cell-cycle arrest, DNA repair or apoptosis. Chk2 acts as a tumor suppressor; loss-of-function mutations impair DNA-damage response and elevate tumor risk.
Localization
Nucleus
Research Area
癌症
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:2000
IHC
1:200-1:2000
ICC/IF
1:100-1:500
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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