Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-Hsp27 Mouse mAb [03E35]
抗Hsp27小鼠单克隆抗体 [03E35]
Cat. No.
A33068
Clone No. 03E35
SynonymsHsp27, HSP27, CMT2F, HMN2B, HMND3, HSP27, HSP28, Hsp25, SRP27, HS.76067, HEL-S-102
详细信息 Product Information
Buffer
0.05% preservative in PBS (pH 7.2-7.4)
Purification
Affinity-purified
Concentration
1 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
27 kDa
Clonality
Monoclonal
Clone No.
03E35
Isotype
IgG
抗原与靶点信息 Antigen & Target Information
Gene Name
HSPB1
Protein Name
Heat-shock-protein-27
Domain
Full length
Background
HSP27 (Heat shock protein 27) belongs to the small heat-shock protein (sHSP) family and resides mainly in cytoplasm, forming oligomeric complexes for chaperone activity. It binds denatured polypeptides and prevents irreversible protein aggregation to shield cells from heat shock, oxidative stress and cytotoxic insults. HSP27 participates in cytoskeleton remodeling and anti-apoptotic regulation to control cell survival and migration. Phosphorylation remodels its oligomer assembly and switches biological activities. Elevated HSP27 is frequently detected in multiple malignancies, correlating with metastasis and chemoresistance; it also contributes to inflammation and neuronal injury.
Localization
Cytoplasm, Nucleus
Research Area
细胞生物学
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:2000
ICC/IF
1:100-1:500
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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