Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-Hsp70 Mouse mAb [96H23]
抗Hsp70小鼠单克隆抗体 [96H23]
Cat. No.
A33071
Clone No. 96H23
SynonymsHsp70, HSP70, HSP70, HSP72, HSPA1, HSP70I, HSP70-1, HSP70-2, HSP70.1, HSP70.2, HSP70-1A, HEL-S-103
详细信息 Product Information
Buffer
0.05% preservative in PBS (pH 7.2-7.4)
Purification
Affinity-purified
Concentration
1 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
70 kDa
Clonality
Monoclonal
Clone No.
96H23
Isotype
IgG
抗原与靶点信息 Antigen & Target Information
Gene Name
HSPA1A
Protein Name
Inducible heat-shock-70-kDa protein
Domain
Full length
Background
Hsp70 (Heat shock protein 70) is a highly-conserved HSP70-family molecular chaperone localized in cytoplasm and nucleus. It folds nascent peptides, refolds misfolded proteins and targets defective polypeptides for degradation, defending cells against heat, oxidation and toxic stress. Hsp70 modulates cell-cycle progression and apoptotic signaling to sustain cellular homeostasis, and its transcription is robustly stress-inducible. Overexpressed Hsp70 supports tumor survival, suppresses apoptosis and confers radio-chemoresistance; it is also implicated in protein-aggregation-related neurodegeneration.
Localization
Cytoplasm
Research Area
细胞生物学
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:2000
IHC
1:200-1:2000
IF-P
1:200-1:2000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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