Anti-IκBα Mouse mAb [51H54]

Affinity-purified

NF-Kappa-B inhibitor-alpha

Full length

IκB-α (NF-κB inhibitor alpha) is a cytoplasmic anchoring protein of IκB inhibitor family. It negatively controls NF-κB transcription factor: under basal conditions, IκB-α sequesters NF-κB dimers in cytoplasm and blocks nuclear transcriptional activity. Inflammatory triggers induce IκB-α phosphorylation, ubiquitination and proteasomal degradation, liberating NF-κB for nuclear import and pro-inflammatory-gene transcription. De-novo synthesized IκB-α provides negative feedback to terminate NF-κB activity. IκB-α degradation serves as a hallmark of NF-κB pathway activation.

Cytoplasm