Anti-p27 Kip1 Mouse mAb [44B35]

Affinity-purified

Cyclin-dependent kinase inhibitor-1B

Full length

p27KIP1 (CDKN1B, cyclin-dependent kinase inhibitor 1B) is a Cip/Kip-family CDK inhibitor mediating G1-phase repression, proliferation restraint and differentiation. p27KIP1 binds and suppresses Cyclin E-CDK2 and Cyclin A-CDK2 complexes, blocks Rb phosphorylation and restrains G1-S transition. Its abundance is mainly governed by post-translational degradation: mitogenic signals trigger ubiquitin-proteasome-dependent p27 turnover to permit proliferation. Anti-proliferative stimuli stabilize p27 and induce cell-cycle arrest. Acting as tumor suppressor, p27 down-regulation is frequent in human cancers and correlates with poor prognosis. It also modulates cell migration and autophagy.

Cytoplasm, Nucleus