Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-p27 Kip1 Mouse mAb [44B35]
抗p27 Kip1小鼠单克隆抗体 [44B35]
Cat. No.
A33099
Clone No. 44B35
Synonymsp27 Kip1, p27-Kip1, KIP1, MEN4, CDKN4, MEN1B, P27KIP1
详细信息 Product Information
Buffer
0.05% preservative in PBS (pH 7.2-7.4)
Purification
Affinity-purified
Concentration
1 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
27 kDa
Clonality
Monoclonal
Clone No.
44B35
Isotype
IgG
抗原与靶点信息 Antigen & Target Information
Gene Name
CDKN1B
Protein Name
Cyclin-dependent kinase inhibitor-1B
Domain
Full length
Background
p27KIP1 (CDKN1B, cyclin-dependent kinase inhibitor 1B) is a Cip/Kip-family CDK inhibitor mediating G1-phase repression, proliferation restraint and differentiation. p27KIP1 binds and suppresses Cyclin E-CDK2 and Cyclin A-CDK2 complexes, blocks Rb phosphorylation and restrains G1-S transition. Its abundance is mainly governed by post-translational degradation: mitogenic signals trigger ubiquitin-proteasome-dependent p27 turnover to permit proliferation. Anti-proliferative stimuli stabilize p27 and induce cell-cycle arrest. Acting as tumor suppressor, p27 down-regulation is frequent in human cancers and correlates with poor prognosis. It also modulates cell migration and autophagy.
Localization
Cytoplasm, Nucleus
Research Area
癌症
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:2000
IHC
1:200-1:2000
ICC/IF
1:100-1:500
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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