Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-PI3 Kinase p85 Mouse mAb [79C82]
抗PI3 Kinase p85小鼠单克隆抗体 [79C82]
Cat. No.
A33108
Clone No. 79C82
SynonymsPI3 Kinase p85, PI3K-p85α, p85, AGM7, GRB1, IMD36, p85alpha, p85-ALPHA
详细信息 Product Information
Buffer
0.05% preservative in PBS (pH 7.2-7.4)
Purification
Affinity-purified
Concentration
1 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
85 kDa
Clonality
Monoclonal
Clone No.
79C82
Isotype
IgG
抗原与靶点信息 Antigen & Target Information
Gene Name
PIK3R1
Protein Name
Phosphatidylinositol-3-kinase regulatory subunit-1
Domain
Full length
Background
PIK3R1 (PI3-kinase p85α, phosphoinositide-3-kinase regulatory subunit alpha) belongs to PI3K regulatory-subunit family and assembles PI3K holoenzyme for RTK-downstream signal transduction. As regulatory component of PI3K heterodimer, p85α harbors SH2 domains that bind phosphorylated tyrosine residues on activated receptor tyrosine kinases. It recruits p110 catalytic subunit to plasma membrane to trigger PI3K activity, converting PIP2 into PIP3 and initiating AKT signaling. Free p85α exerts inhibitory effect on p110 to keep pathway quiescent. Mutation and dysregulation of p85α are linked to malignancy and immune disorders.
Localization
Cytoplasm
Research Area
细胞生物学
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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