Anti-PRKAA1 Mouse mAb [12F95]

Affinity-purified

5'-AMP-activated protein kinase catalytic subunit-alpha-1

Full length

AMPKα1 (AMP-activated protein kinase α1 catalytic subunit) is a key catalytic isoform of the AMPK serine/threonine kinase family, encoded by the PRK aa1 gene, with a molecular weight of approximately 63 kDa. As a core energy-sensing protein in eukaryotic cells, AMPKα1 is widely distributed in most peripheral tissues, functioning as the primary catalytic subunit responsible for AMPK activation and downstream signal transduction. It precisely monitors cellular energy status, regulates glucose uptake, fatty acid oxidation, mitochondrial biogenesis and autophagy processes, and maintains intracellular energy and metabolic homeostasis. AMPKα1 dysfunction leads to energy metabolism disorders, insulin resistance, inflammatory responses and oxidative stress, which are closely involved in the occurrence and development of obesity, diabetes, cardiovascular diseases and tumors.

Cytoplasm