Anti-ACE2 Rabbit mAb [10H04]

Protein A affinity purification

Angiotensin-converting enzyme 2

ACE2 (Angiotensin-converting enzyme 2) belongs to the angiotensin-converting enzyme family and mediates negative regulation of the renin-angiotensin system. ACE2 is a membrane-bound carboxypeptidase predominantly expressed on pulmonary, cardiac, renal and intestinal epithelial cells. It catalyzes conversion of angiotensin II into angiotensin 1-7, counteracting ACE-driven vasoconstriction and inflammation to exert protective effects that maintain cardiovascular, pulmonary and renal homeostasis. ACE2 also serves as the functional receptor for coronavirus entry, as SARS-CoV and SARS-CoV-2 spike proteins bind ACE2 to mediate viral infection, making ACE2 central to COVID-19 infection mechanisms. Its expression level and proteolytic shedding modulate viral susceptibility. ACE2 is widely studied in cardiovascular disease, lung injury, viral infection and drug-target researches.

Cell membrane