Anti-pan AKT Rabbit mAb [19A03]

Protein A affinity purification

RAC-alpha/beta/gamma serine/threonine-protein kinase

Pan-AKT (pan-protein kinase B) is a core member of the serine/threonine protein kinase family, consisting of three highly homologous isoforms: Akt1, Akt2, and Akt3, which function as pivotal signaling hubs in cells. Akt1 is ubiquitously expressed in various tissues and regulates cell survival and proliferation; Akt2 is mainly responsible for glycolipid metabolic modulation; Akt3 is predominantly enriched in neural tissues and mediates cell development and differentiation. Targeting the conserved domains of all three isoforms, pan-Akt broadly recognizes total Akt proteins and transduces upstream PI3K signals to activate downstream cascades, governing multiple fundamental biological processes including cell proliferation, apoptosis, metabolism, autophagy, migration, and immune responses. Abnormal activation or overexpression of Akt family proteins drives tumor proliferation, metabolic disorders, inflammatory imbalance, and tissue fibrosis, rendering Akt a key hotspot target for tumor and metabolic disease research.

Cytoplasm, Nucleus