Anti-ALIX Rabbit mAb [88A15]

Protein A affinity purification

ALG-2-interacting protein X

ALIX (Apoptosis-Linked Gene 2-Interacting Protein X) is a conserved multifunctional scaffold protein belonging to the ESCRT (Endosomal Sorting Complex Required for Transport) accessory protein family, encoded by the PDCD6IP gene with a molecular weight of approximately 95 kDa. It is ubiquitously expressed in most mammalian cells and tissues, serving as a core regulator of endosomal trafficking, vesicle budding, and extracellular vesicle biogenesis. ALIX participates in multiple key biological processes, including endosomal sorting, exosome secretion, cytokinesis completion, and virus budding. It also interacts with apoptosis-related proteins to modulate cellular apoptosis and stress responses. Abnormal expression of ALIX affects exosome release and intracellular material transport, closely associated with tumor metastasis, inflammatory injury, and viral infection progression.

Cytoplasm