Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-ATG7 Rabbit mAb [56E53]
抗ATG7兔单克隆抗体 [56E53]
Cat. No.
A52011
Clone No. 56E53
SynonymsATG7, APG7-L, Apg7p, ATG7L1
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
78 kDa
Observed MW
78 kDa
Clonality
Monoclonal
Clone No.
56E53
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
ATG7
Protein Name
Autophagy-related protein 7
Background
ATG7 (Autophagy Related Protein 7) is an essential ubiquitin-activating enzyme-like protein of the ATG superfamily, encoded by the ATG7 gene with a molecular weight of approximately 78 kDa, and serves as a core prerequisite factor for cellular autophagy. Ubiquitously expressed in mammalian cells, ATG7 primarily initiates and catalyzes autophagosome formation by mediating LC3 lipidation and ATG12-ATG5 complex assembly, which are indispensable steps for canonical macroautophagy. It participates in the degradation of damaged organelles, clearance of misfolded proteins, nutritional stress response and cellular homeostasis maintenance. Dysregulated ATG7 expression causes autophagy dysfunction, which is closely associated with tumorigenesis, neurodegeneration, metabolic injury and inflammatory disorders.
Localization
Cytoplasm
Research Area
细胞生物学
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IHC
1:200-1:1000
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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