Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-ATF6A Rabbit mAb [59H37]
抗ATF6A兔单克隆抗体 [59H37]
Cat. No.
A52012
Clone No. 59H37
SynonymsATF6A, ATF6α, cAMP-dependent transcription factor ATF-6 alpha
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
75 kDa
Observed MW
100 kDa
Clonality
Monoclonal
Clone No.
59H37
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
ATF6A
Protein Name
Activating transcription factor 6 alpha
Background
ATF6A (Activating Transcription Factor 6A) is a key member of the basic leucine zipper (bZIP) transcription factor family encoded by the ATF6A gene, functioning as a central regulator of the endoplasmic reticulum stress (ERS) pathway. Localized on the endoplasmic reticulum membrane, ATF6A maintains low basal expression under physiological conditions. Upon ER stress and protein folding dysfunction, ATF6A is cleaved and activated, translocates to the nucleus, and initiates the transcription of downstream ER stress repair genes to regulate protein folding, ER homeostasis restoration and cell survival. Sustained abnormal activation of ATF6A triggers chronic ER stress, induces cell apoptosis, metabolic disorders and inflammatory damage, and contributes to tumor proliferation, diabetic complications, cardiovascular injury and neurological diseases.
Localization
Endoplasmic Reticulum
Research Area
细胞生物学
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IP
1:50-1:200
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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