Anti-ATP5A Rabbit mAb [06C56]

Protein A affinity purification

ATP synthase F1 subunit alpha, mitochondrial

ATP5A is the α subunit of the F1 domain of mitochondrial ATP synthase, encoded by the ATP5A1 gene with a molecular weight of approximately 55 kDa, and acts as a pivotal functional protein for mitochondrial energy metabolism. Stably expressed on the inner mitochondrial membrane, ATP5A serves as a core catalytic component of ATP synthase. It primarily participates in mitochondrial oxidative phosphorylation, catalyzes ADP phosphorylation to generate ATP, provides major energy support for cellular life activities, and maintains mitochondrial structural integrity and energy homeostasis. Downregulated expression or dysfunction of ATP5A directly causes impaired mitochondrial energy synthesis, accumulated oxidative stress and cellular metabolic failure, which is closely related to cell apoptosis, senescence, tumor metabolic reprogramming, myocardial injury and neurodegenerative diseases.

Mitochondrion