Anti-ATPB Rabbit mAb [15H23]

Protein A affinity purification

ATP synthase F1 subunit beta, mitochondrial

ATPB is the β subunit of the F1 domain of mitochondrial ATP synthase, encoded by the ATP5B gene with a molecular weight of approximately 52 kDa, and functions as a core catalytic subunit of the mitochondrial oxidative phosphorylation system. Assembled with ATP5A to form the catalytic core of ATP synthase, ATPB is widely distributed on the inner mitochondrial membrane of high-energy-consuming cells. It acts as a key rate-limiting component for cellular ATP synthesis, sustains mitochondrial morphological stability and metabolic homeostasis. Defective function or abnormal expression of ATPB severely impairs mitochondrial energy production, induces oxidative stress damage, cell cycle arrest and apoptosis, and participates in the pathological progression of tumors, metabolic disorders, myocardial ischemic injury and neuropathy.

Mitochondrion