Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-Aurora B Rabbit mAb [87H88]
抗Aurora B兔单克隆抗体 [87H88]
Cat. No.
A52015
Clone No. 87H88
SynonymsAurora B, Aurora-B, AIK2, AIM1, ARK2, PPP1R48, STK-1, STK5, AURK2
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
39 kDa
Observed MW
39 kDa
Clonality
Monoclonal
Clone No.
87H88
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
AURKB
Protein Name
Aurora kinase B
Background
Aurora B is a core member of the Aurora serine/threonine kinase family encoded by the AURKB gene, serving as a crucial regulator of cell mitosis. Enriched during mitosis and localized at centromeres and spindle midzone, Aurora B governs precise chromosome alignment, spindle assembly checkpoint surveillance, sister chromatid segregation and cytokinesis completion, ensuring the accuracy and stability of cell division. Abnormal overexpression or hyperactivation of Aurora B leads to chromosome segregation errors, genomic instability and uncontrolled cell proliferation, acting as a vital driver of tumorigenesis, invasion and metastasis and a promising target for tumor targeted therapy.
Localization
Nucleus
Research Area
癌症
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IHC
1:500-1:1000
IP
1:50-1:200
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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