Anti-Bad Rabbit mAb [69F49]

Protein A affinity purification

Bcl-2-associated agonist of cell death

Bad (Bcl-2-associated agonist of cell death) is a pro-apoptotic member of the Bcl-2 protein family encoded by the BAD gene, acting as a key regulator of the mitochondrial apoptotic pathway. Ubiquitously expressed in various tissues and cells, Bad promotes endogenous apoptosis by binding and antagonizing anti-apoptotic proteins including Bcl-2 and Bcl-XL, triggering mitochondrial membrane potential collapse and cytochrome C release. Phosphorylation-induced Bad inactivation sequesters the protein in the cytoplasm and blocks apoptosis. The dysregulation of Bad expression and activation disrupts the balance between cell survival and apoptosis, closely participating in tumorigenesis, oxidative damage, metabolic disorders and neurodegenerative diseases.

Cytoplasm