Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-Bad Rabbit mAb [69F49]
抗Bad兔单克隆抗体 [69F49]
Cat. No.
A52017
Clone No. 69F49
SynonymsBad, BAD, BCL2L8
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
18 kDa
Observed MW
23 kDa
Clonality
Monoclonal
Clone No.
69F49
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
BAD
Protein Name
Bcl-2-associated agonist of cell death
Background
Bad (Bcl-2-associated agonist of cell death) is a pro-apoptotic member of the Bcl-2 protein family encoded by the BAD gene, acting as a key regulator of the mitochondrial apoptotic pathway. Ubiquitously expressed in various tissues and cells, Bad promotes endogenous apoptosis by binding and antagonizing anti-apoptotic proteins including Bcl-2 and Bcl-XL, triggering mitochondrial membrane potential collapse and cytochrome C release. Phosphorylation-induced Bad inactivation sequesters the protein in the cytoplasm and blocks apoptosis. The dysregulation of Bad expression and activation disrupts the balance between cell survival and apoptosis, closely participating in tumorigenesis, oxidative damage, metabolic disorders and neurodegenerative diseases.
Localization
Cytoplasm
Research Area
癌症
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IHC
1:200-1:1000
IP
1:50-1:200
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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