Anti-Bax Rabbit mAb [79C45]

Protein A affinity purification

Bcl-2-associated X protein

Bax (Bcl-2-associated X protein) is a core pro-apoptotic member of the Bcl-2 family encoded by the BAX gene and serves as a crucial effector of the mitochondrial apoptosis pathway. Distributed mainly in the cytoplasm under physiological conditions, Bax undergoes conformational changes and translocates to the outer mitochondrial membrane upon apoptotic stimulation, forming membrane pores to trigger mitochondrial permeability transition and the release of cytochrome C and apoptotic factors, thereby initiating cascade apoptotic responses. Bax dynamically balances with anti-apoptotic Bcl-2 family proteins to maintain cellular apoptotic homeostasis. Downregulated expression or functional inhibition of Bax enables tumor cells to evade apoptosis and achieve unlimited proliferation, which is widely involved in tumors, inflammatory injury, aging and metabolic diseases.

Cytoplasm