Anti-Bcl-2 Rabbit mAb [71E77]

Protein A affinity purification

B-cell lymphoma-2

Bcl-2 (B-cell lymphoma-2) is a classic anti-apoptotic member of the Bcl-2 protein family encoded by the BCL2 gene, functioning as a central hub balancing cell survival and apoptosis. Predominantly localized on the outer mitochondrial membrane, endoplasmic reticulum and nuclear membrane, Bcl-2 binds and sequesters pro-apoptotic proteins such as Bax and Bad, inhibits mitochondrial pore formation and the release of apoptotic factors, and blocks the endogenous apoptotic pathway to sustain cell survival. Aberrant overexpression of Bcl-2 significantly enhances anti-apoptotic capacity, driving abnormal cell proliferation, drug resistance and malignant transformation. It serves as a critical biomarker for tumor progression, chemotherapy resistance and poor prognosis, as well as a well-established target for tumor targeted therapy.

Cytoplasmic, Mitochondrial