Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-Bcl-XL Rabbit mAb [44F36]
抗Bcl-XL兔单克隆抗体 [44F36]
Cat. No.
A52020
Clone No. 44F36
SynonymsBcl-XL, Bcl-x, BCL2L1, BCL2L, BCLX, Bcl-2-like protein 1, Bcl2-L-1, Apoptosis regulator Bcl-X
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
26 kDa
Observed MW
30 kDa
Clonality
Monoclonal
Clone No.
44F36
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
BCL2L1
Protein Name
Bcl-2-like protein 1
Background
Bcl-XL (Bcl-2-like protein 1) is a vital anti-apoptotic isoform of the Bcl-2 family encoded by the BCL2L1 gene with a molecular weight of approximately 26 kDa, acting as an essential pro-survival protein for cellular homeostasis. Mainly enriched on the outer mitochondrial membrane, Bcl-XL shares high functional similarity with Bcl-2, efficiently binding pro-apoptotic proteins including Bax, Bad and Bak to inhibit mitochondrial apoptotic pathway activation and block programmed cell death. It also participates in the regulation of cell cycle, oxidative stress and energy metabolism. Widely expressed in various tissues and abnormally upregulated in tumors, Bcl-XL is a key driver of tumor anti-apoptosis, proliferation, invasion and targeted drug resistance, exhibiting more prominent regulatory effects in solid tumors than Bcl-2.
Localization
Mitochondrion
Research Area
癌症
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IHC
1:200-1:1000
IP
1:50-1:200
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
相关产品 Related Products
Anti-IL-1β Rabbit mAb [99F42]
WBIPIFELISA
Anti-Polycomb Protein SUZ12 Rabbit mAb [36G88]
WBIHCIPIFELISA
价格与规格
该产品暂未录入规格价格，请联系我们获取报价与现货情况。