Anti-Carbonic Anhydrase 9 Rabbit mAb [93G29]

Protein A affinity purification

Carbonic anhydrase 9

Carbonic Anhydrase 9 (CA9) is a zinc metalloenzyme and transmembrane glycoprotein belonging to the α-carbonic anhydrase family, encoded by the CA9 gene and serves as a typical hypoxia-inducible tumor-associated biomarker. It catalyzes the reversible hydration of carbon dioxide into bicarbonate and protons to regulate intracellular and extracellular pH homeostasis. Specifically induced and highly expressed in hypoxic solid tumor regions while rarely detected in normal tissues, CA9 remodels the acidic tumor microenvironment to facilitate cancer cell proliferation, invasion, metastasis and chemoresistance. It also participates in cell adhesion modulation and metabolic reprogramming, driving malignant progression of multiple tumors such as clear cell renal cell carcinoma and lung cancer.

Cell membrane