Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-Calnexin Rabbit mAb [32G08]
抗Calnexin兔单克隆抗体 [32G08]
Cat. No.
A52024
Clone No. 32G08
SynonymsCalnexin, p90, IP90
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
68 kDa
Observed MW
90 kDa
Clonality
Monoclonal
Clone No.
32G08
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
CANX
Protein Name
Calnexin
Background
Calnexin is an endoplasmic reticulum-resident type I transmembrane chaperone protein encoded by the CANX gene, acting as a core component of the ER protein folding quality control system. Ubiquitously expressed in eukaryotic cells, Calnexin primarily mediates the folding, modification and assembly of newly synthesized glycosylated proteins, retains misfolded proteins in the ER to prevent abnormal protein trafficking, and ensures correct protein maturation and degradation to maintain ER homeostasis. It also participates in ER stress response, intracellular calcium homeostasis regulation and apoptosis modulation, serving as a classic specific ER biomarker. Calnexin dysfunction causes protein folding disorders and excessive ER stress activation, closely involved in metabolic injury, inflammation and tumor progression.
Localization
Endoplasmic Reticulum
Research Area
细胞生物学
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IHC
1:2000-1:10000
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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