Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-β-Catenin (phospho Ser675) Rabbit mAb [29A04]
抗β-Catenin (phospho Ser675)兔单克隆抗体 [29A04]
Cat. No.
A52039
Clone No. 29A04
Synonymsβ-Catenin (phospho Ser675), p-β-Catenin(Ser675), ARMADILLO, ARM, CATNB, BCL9
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
85 kDa
Observed MW
85 kDa
Modification
Phospho
Clonality
Monoclonal
Clone No.
29A04
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
CTNNB1
Protein Name
β-Catenin (phospho Ser675)
Background
Phospho-β-Catenin (Ser675) is an activated post-translational modification form of β-Catenin, with Ser675 serving as a key phosphorylation site mediated by PKA and other kinases. Phosphorylation at Ser675 enhances β-Catenin stability, promotes its nuclear translocation and accumulation, and potently activates the canonical Wnt signaling pathway to upregulate downstream target gene transcription, thereby regulating cell proliferation, stemness maintenance, migration, invasion and tissue remodeling. Excessive Ser675 phosphorylation is a hallmark of aberrant Wnt pathway activation, widely involved in tumor overproliferation, fibrosis, developmental abnormalities and metabolic disorders.
Localization
Cytoplasm, Nucleus
Research Area
细胞生物学
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:500-1:2000
IP
1:50-1:200
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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