Anti-β-Catenin Rabbit mAb [34A86]

Protein A affinity purification

Beta-catenin

β-Catenin is a core member of the catenin superfamily encoded by the CTNNB1 gene and serves as a central hub of the canonical Wnt signaling pathway. It possesses dual structural and signaling functions. Membrane-localized β-catenin participates in adherens junction assembly to maintain cell polarity and tissue homeostasis, while cytoplasmic and nuclear β-catenin acts as a key signaling transducer to regulate downstream target gene expression, governing fundamental biological processes including cell proliferation, differentiation, apoptosis, migration and embryonic development. Dysregulated β-catenin homeostasis and aberrant nuclear accumulation lead to constitutive Wnt pathway activation, driving malignant tumor proliferation, invasion, metastasis and fibrosis progression. It is a critical research target for tumors, metabolic disorders and developmental abnormalities.

Cytoplasm