Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-β-Catenin (phospho Ser37) Rabbit mAb [45C30]
抗β-Catenin (phospho Ser37)兔单克隆抗体 [45C30]
Cat. No.
A52041
Clone No. 45C30
Synonymsβ-Catenin (phospho Ser37), p-β-Catenin(Ser37), ARMADILLO, ARM, CATNB, BCL9
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
86 kDa
Observed MW
86 kDa
Modification
Phospho
Clonality
Monoclonal
Clone No.
45C30
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
CTNNB1
Protein Name
β-Catenin (phospho Ser37)
Background
β-catenin (Catenin beta-1) belongs to the cadherin-associated protein family and exerts dual functions in cell-cell adhesion and Wnt signal transduction. As a component of cell adhesion complex, it localizes beneath plasma membrane and bridges E-cadherin to cytoskeleton to preserve epithelial tissue architecture. It also serves as the central effector of Wnt signaling. In the absence of Wnt ligands, β-catenin is recognized by destruction complex and phosphorylated at Ser37, which triggers ubiquitin-proteasome-dependent degradation and keeps its cellular abundance low. Upon Wnt activation, Ser37 phosphorylation is suppressed, allowing β-catenin translocation into nucleus to interact with TCF/LEF transcription factors, modulating cell proliferation, differentiation, apoptosis and oncogenesis. Phosphorylation at Ser37 is a hallmark for β-catenin primed for degradation, widely applied in oncology and developmental biology research.
Localization
Cytoplasm, Nucleus
Research Area
细胞生物学
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:500-1:2000
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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