Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-CD105 Rabbit mAb [36B50]
抗CD105兔单克隆抗体 [36B50]
Cat. No.
A52044
Clone No. 36B50
SynonymsCD105, ENDOGLIN
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
70 kDa
Observed MW
95 kDa
Clonality
Monoclonal
Clone No.
36B50
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
ENG
Protein Name
Endoglin
Background
CD105 (Endoglin) is a co-receptor of TGF-β receptor superfamily and functions in modulating TGF-β superfamily signaling. Predominantly expressed on proliferating vascular endothelial cells, CD105 is also detected on subsets of stem cells and tumor cells. As a co-receptor, it binds TGF-β1 and TGF-β3 and tunes downstream Smad cascades to regulate endothelial proliferation, migration and angiogenesis. Physiologically, it contributes to embryonic vascular development and tissue injury repair. In pathological contexts, CD105 is highly enriched on tumor neovessels, promoting angiogenesis to sustain tumor growth and distant metastasis. CD105 acts as a well-established marker for tumor neovascularization, applied for angiogenesis assessment, anti-angiogenic drug efficacy testing, stem cell characterization and vascular disease research.
Research Area
癌症
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IHC
1:100-1:200
IP
1:50-1:200
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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