Anti-LAMP2 Rabbit mAb [94B84]

Protein A affinity purification

Lysosome-associated membrane protein-2

LAMP2 (Lysosome-associated membrane protein 2) belongs to the lysosomal membrane glycoprotein family. It maintains lysosomal membrane stability and mediates autophagosome-lysosome fusion. LAMP2 is highly enriched on the surface of lysosomal membranes. Its heavily glycosylated structure protects the lysosomal membrane from degradation by luminal hydrolases. Meanwhile, LAMP2 participates in autophagosome-lysosome fusion and serves as a critical molecule for intact autophagic flux. LAMP2 has multiple splice variants that localize to lysosomes or the cell membrane respectively, and functional differences among these variants affect intracellular cargo transport. Defects in the LAMP2 gene cause Danon disease, characterized by lysosomal storage, myocardial and skeletal muscle lesions. In tumor cells, LAMP2 contributes to stress tolerance via autophagy, making it a classic marker for lysosome and autophagy research.

Lysosome