Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-LAMP2 Rabbit mAb [94B84]
抗LAMP2兔单克隆抗体 [94B84]
Cat. No.
A52045
Clone No. 94B84
SynonymsLAMP2, LAMP-II, HSP73, GILT, LAMP-2
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
45 kDa
Observed MW
120 kDa
Clonality
Monoclonal
Clone No.
94B84
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
LAMP2
Protein Name
Lysosome-associated membrane protein-2
Background
LAMP2 (Lysosome-associated membrane protein 2) belongs to the lysosomal membrane glycoprotein family. It maintains lysosomal membrane stability and mediates autophagosome-lysosome fusion. LAMP2 is highly enriched on the surface of lysosomal membranes. Its heavily glycosylated structure protects the lysosomal membrane from degradation by luminal hydrolases. Meanwhile, LAMP2 participates in autophagosome-lysosome fusion and serves as a critical molecule for intact autophagic flux. LAMP2 has multiple splice variants that localize to lysosomes or the cell membrane respectively, and functional differences among these variants affect intracellular cargo transport. Defects in the LAMP2 gene cause Danon disease, characterized by lysosomal storage, myocardial and skeletal muscle lesions. In tumor cells, LAMP2 contributes to stress tolerance via autophagy, making it a classic marker for lysosome and autophagy research.
Localization
Lysosome
Research Area
细胞生物学
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IHC
1:200-1:1000
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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