Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-CD117/c-Kit Rabbit mAb [50B87]
抗CD117/c-Kit兔单克隆抗体 [50B87]
Cat. No.
A52046
Clone No. 50B87
SynonymsCD117/c-Kit, c-Kit / CD117, CD117, SCFR, c-Kit, p145KIT
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
110 kDa
Observed MW
130 kDa
Clonality
Monoclonal
Clone No.
50B87
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
KIT
Protein Name
Mast/stem cell growth factor receptor Kit
Background
CD117/c-Kit (Proto-oncogene tyrosine-protein kinase Kit) belongs to class Ⅲ receptor tyrosine kinase family and transduces signaling triggered by stem cell factor SCF. SCF binding induces receptor dimerization and intracellular kinase domain autophosphorylation, activating downstream PI3K, MAPK cascades to govern survival, proliferation and differentiation of hematopoietic stem cells, mast cells, germ cells and melanocytes. Gain-of-function mutations of c-Kit drive gastrointestinal stromal tumor (GIST), certain leukemia and mast cell neoplasms. c-Kit serves as stem-lineage marker as well as oncogenic driver target;small-molecule inhibitors against c-Kit have achieved clinical application for GIST. It is widely used for stem cell profiling, mast cell identification and tumor pathological diagnosis.
Localization
Cell membrane
Research Area
癌症
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:500-1:2000
IP
1:50-1:200
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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