Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-CD11b Rabbit mAb [49A43]
抗CD11b兔单克隆抗体 [49A43]
Cat. No.
A52047
Clone No. 49A43
SynonymsCD11b, MAC-1, CR3α, αM
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
127 kDa
Observed MW
170 kDa
Clonality
Monoclonal
Clone No.
49A43
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
ITGAM
Protein Name
Integrin subunit alpha-M
Background
CD11b (Integrin alpha-M, ITGAM) is a member of β2-integrin family and functions as adhesion, migration and phagocytic receptor for myeloid cells. CD11b non-covalently associates with CD18 to form Mac-1 complex, predominantly expressed on monocytes, macrophages, granulocytes and dendritic cells. Mac-1 recognizes diverse ligands including iC3b and fibrinogen, mediating leukocyte-endothelium adhesion to support myeloid recruitment toward inflammatory foci. It also mediates complement-dependent phagocytosis and modulates immune cell activation and cytokine secretion. CD11b is a canonical myeloid cell surface marker, applied for immune subset discrimination and mechanistic research on inflammation, autoimmune disorders and tumor immune microenvironment.
Localization
Cell membrane
Research Area
免疫和传染性疾病
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:2000-1:10000
IHC
1:4000-1:20000
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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