Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-CD11c Rabbit mAb [71H15]
抗CD11c兔单克隆抗体 [71H15]
Cat. No.
A52048
Clone No. 71H15
SynonymsCD11c, CR4α, αX
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
128 kDa
Observed MW
145 kDa
Clonality
Monoclonal
Clone No.
71H15
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
ITGAX
Protein Name
Integrin subunit alpha-X
Background
CD11c (Integrin alpha-X, ITGAX) belongs to β2-integrin family and participates in myeloid cell adhesion and antigen-presentation-associated regulation. CD11c heterodimerizes with CD18 to form CR4 integrin complex, highly expressed on dendritic cells, and detectable on subsets of macrophages, activated NK cells and granulocytes. CR4 binds complement fragments such as iC3b to facilitate phagocytic clearance of complement-opsonized particles. CD11c is a signature marker for dendritic cell identification and subset stratification. DCs utilize CD11c for tissue residency and antigen capture to initiate adaptive immunity. In tumor immunity, CD11c-positive DCs mediate tumor antigen presentation and shape anti-tumor responses, widely adopted for immune phenotyping, inflammatory models and tumor microenvironment studies.
Localization
Cell membrane
Research Area
免疫和传染性疾病
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:2000-1:10000
IHC
1:200-1:1000
IP
1:50-1:200
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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