Anti-CD133 Rabbit mAb [41E34]

Protein A affinity purification

Prominin-1

CD133 (Prominin-1) is a pentaspan transmembrane glycoprotein family member responsible for plasma membrane protrusion maintenance and stem-cell-related signal regulation. Localized on microvilli and ciliary membrane protrusions, CD133 was first identified as hematopoietic stem cell marker, and later found on multiple tissue stem cells as well as cancer stem cells. CD133 sustains membrane topology, modulates cell polarity and participates in signaling vesicle trafficking. Cumulative evidence demonstrates CD133-positive cancer stem cells possess self-renewal capacity, drug-resistance and high tumorigenicity, correlating with tumor relapse and metastasis. CD133 is commonly used for isolation and characterization of cancer stem cells in brain tumor, colorectal carcinoma and other malignancies, as well as normal tissue stem cell biology investigation.

Cell membrane