Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-CD19 Rabbit mAb [14G68]
抗CD19兔单克隆抗体 [14G68]
Cat. No.
A52050
Clone No. 14G68
SynonymsCD19, B4, Bp50, BPI, B-lyc
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Observed MW
110 kDa
Clonality
Monoclonal
Clone No.
14G68
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
CD19
Protein Name
B-lymphocyte antigen CD19
Background
CD19 (B-lymphocyte antigen CD19) belongs to immunoglobulin superfamily and acts as co-regulator for B-cell receptor signaling. CD19 exhibits B-lineage-restricted expression from early B-cell progenitors up to pre-plasma cell stage. As BCR co-receptor, CD19 assembles with CD21 and CD81 to amplify BCR downstream signaling cascades, governing B-cell proliferation, differentiation and antibody production to sustain humoral immunity. CD19 deficiency leads to impaired humoral immune response. B-cell malignancies including B-ALL and diffuse large B-cell lymphoma frequently retain CD19 expression, making it a canonical target for CAR-T therapy. CD19 is applied for B-lymphocyte subset profiling, B-cell-associated hematological malignancy diagnosis and immunological research.
Localization
Cell membrane
Research Area
肿瘤免疫
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IHC
1:200-1:1000
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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