Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-CD20 Rabbit mAb [10H52]
抗CD20兔单克隆抗体 [10H52]
Cat. No.
A52051
Clone No. 10H52
SynonymsCD20, Bp35, Bp39, MB-5
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
33 kDa
Observed MW
36 kDa
Clonality
Monoclonal
Clone No.
10H52
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
MS4A1
Protein Name
B-lymphocyte antigen CD20
Background
CD20 (B-lymphocyte surface antigen CD20, MS4A1) is a MS4A-family transmembrane protein that modulates B-lymphocyte activation and proliferation. CD20 is expressed from pre-B cell to mature B-cell stages and down-regulated upon plasma cell differentiation. Located on plasma membrane, CD20 modulates calcium flux and participates in B-cell receptor signaling network to shape B-cell activation and cell-cycle progression. Absent from hematopoietic stem cells, CD20 targeting depletes mature B-cells while sparing B-cell progenitors. CD20 represents a well-validated therapeutic target for B-cell lymphoma and autoimmune diseases. It is also widely used as biomarker for flow cytometry and IHC in B-cell neoplasm classification and B-cell status evaluation in autoimmune disorders.
Localization
Cell membrane
Research Area
肿瘤免疫
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IHC
1:500-1:1000
IP
1:50-1:200
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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