Anti-CD206/MRC1 Rabbit mAb [71A92]

Protein A affinity purification

Mannose receptor C-type 1

CD206/MRC1 (Mannose receptor C-type 1) is a member of the C-type lectin superfamily, which performs pattern recognition, endocytosis and macrophage phenotype regulation. This molecule is predominantly expressed on M2-type macrophages and subsets of dendritic cells. Its extracellular domain recognizes mannose- and fucose-modified pathogens and apoptotic cell debris, mediating endocytic clearance of ligands. CD206 participates in tissue repair and anti-inflammatory immune responses. In the tumor microenvironment, tumor-associated macrophages highly express CD206, promoting the formation of an immunosuppressive microenvironment and facilitating tumor progression. CD206 serves as a classic surface marker for M2-like macrophages and is widely applied in studies of tissue immune microenvironment, inflammatory models, tumor immunity and pathogen immune escape mechanisms.

Cell membrane