Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-CD21 Rabbit mAb [26A43]
抗CD21兔单克隆抗体 [26A43]
Cat. No.
A52053
Clone No. 26A43
SynonymsCD21, HEB, EBV R, C3D2R
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
113 kDa
Observed MW
155 kDa
Clonality
Monoclonal
Clone No.
26A43
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
CR2
Protein Name
Complement C3d receptor 2
Background
CD21 (Complement receptor 2, CR2) is a member of complement control protein family and mediates complement fragment recognition as well as B-cell co-stimulation. Mainly expressed on mature B-lymphocytes and follicular dendritic cells, CD21 binds complement cleavage product C3d and assembles with CD19-CD81 co-receptor complex to lower B-cell activation threshold, amplify BCR signaling and promote B-cell proliferation and memory B-cell generation. Follicular dendritic cell-resident CD21 captures complement-coated antigens to support antigen presentation and immune memory maintenance. CD21 contributes to humoral immunity; its dysregulated expression correlates with autoimmune disorders and B-cell malignancies. It is applied for B-cell subset identification, follicular dendritic cell labeling, lymphoid tissue pathology and immune-response mechanistic research.
Localization
Cell membrane
Research Area
免疫和传染性疾病
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IHC
1:1000-1:4000
IP
1:50-1:200
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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