50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
60-80 kDa
Clonality
Monoclonal
Clone No.
74G79
Isotype
IgG, Kappa
抗原与靶点信息
Antigen & Target Information
Gene Name
CD86
Protein Name
CD86 molecule
Background
CD86 (Cluster of differentiation 86, B7-2) belongs to B7 co-stimulatory superfamily and delivers co-stimulatory signals for T-cell activation. Predominantly expressed on antigen-presenting cells including dendritic cells, macrophages and B-cells, CD86 maintains low basal expression and is strongly up-regulated upon inflammatory stimulation. It engages T-cell surface CD28 to deliver positive co-stimulation, cooperating with MHC-TCR signaling to drive T-cell proliferation, differentiation and cytokine secretion for adaptive immunity initiation. CD86 also binds CTLA-4 to transmit inhibitory signals for immune homeostasis.