Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-CDC37 (phospho Ser13) Rabbit mAb [76F36]
抗CDC37 (phospho Ser13)兔单克隆抗体 [76F36]
Cat. No.
A52071
Clone No. 76F36
SynonymsCDC37 (phospho Ser13), p-CDC37(Ser13), p60-p75, HSP90-cofactor p59
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
44 kDa
Observed MW
44 kDa
Modification
Phospho
Clonality
Monoclonal
Clone No.
76F36
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
CDC37
Protein Name
CDC37 (phospho Ser13)
Background
CDC37 (Cell-division-cycle 37, Phospho-Ser13) is a co-factor of Hsp90 chaperone complex and supports folding and stabilization of kinase clients. Acting as a chaperone adaptor, CDC37 selectively binds diverse kinase substrates and recruits them to Hsp90 complex, shielding kinases from ubiquitin-dependent degradation and maintaining native protein conformation. Ser13 phosphorylation is critical for CDC37 activation; this modification boosts assembly of CDC37-Hsp90-kinase complex and stabilizes oncogenic kinases including CDKs and RAF. In tumor cells, CDC37 overexpression sustains oncogenic kinase stability and drives malignant phenotypes. Phospho-Ser13 level mirrors CDC37 chaperone-pathway activity and is widely measured in oncogenic-signaling and protein-homeostasis researches.
Localization
Cytoplasm
Research Area
细胞生物学
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IHC
1:400-1:1000
IP
1:50-1:200
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
相关产品 Related Products
Anti-IL-1β Rabbit mAb [99F42]
WBIPIFELISA
Anti-Polycomb Protein SUZ12 Rabbit mAb [36G88]
WBIHCIPIFELISA
价格与规格
该产品暂未录入规格价格，请联系我们获取报价与现货情况。