Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-Cdc2 Rabbit mAb [13A11]
抗Cdc2兔单克隆抗体 [13A11]
Cat. No.
A52072
Clone No. 13A11
SynonymsCdc2, Cell division cycle protein 2 homolog (S. cerevisiae), p34cdc2, MPM2 antigen
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
34 kDa
Observed MW
34 kDa
Clonality
Monoclonal
Clone No.
13A11
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
CDK1
Protein Name
Cyclin-dependent kinase 1
Background
Cdc2 (Cell-division-cycle 2, CDK1) belongs to cyclin-dependent kinase family and serves as master regulator for G2/M transition and mitosis onset. Cdc2 associates with Cyclin B to form maturation-promoting factor (MPF). Its kinase activity is tightly governed by layered phosphorylation. Wee1 introduces inhibitory phosphorylation to keep Cdc2 silent; Cdc25C removes these inhibitory phosphates to activate MPF, triggering nuclear envelope breakdown, spindle assembly and other mitotic events. Cyclin B degradation after mitosis terminates Cdc2 activity. Dysregulated Cdc2 activation causes cell-cycle aberration and genomic instability, and its up-regulation is detected in various cancers.
Localization
Cytoplasm, Nucleus
Research Area
癌症
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:2000-1:10000
IHC
1:1000-1:4000
IP
1:50-1:200
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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