Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-CDK2 Rabbit mAb [27B68]
抗CDK2兔单克隆抗体 [27B68]
Cat. No.
A52073
Clone No. 27B68
SynonymsCDK2, CDC2-related protein kinase p33, p33CDK2, p35CDK2
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
34 kDa
Observed MW
34 kDa
Clonality
Monoclonal
Clone No.
27B68
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
CDK2
Protein Name
Cyclin-dependent kinase 2
Background
CDK2 (Cyclin-dependent kinase 2) is a cyclin-dependent kinase family member controlling G1/S transition and S-phase progression. CDK2 partners with Cyclin E and Cyclin A sequentially to drive G1-to-S checkpoint passage and S-phase DNA replication. Cyclin E-CDK2 complex triggers G1/S transition and DNA-replication initiation; Cyclin A-CDK2 sustains S-phase progression by phosphorylating replication-associated substrates. CDK2 activity is negatively modulated by CKI inhibitors such as p21 and p27. Dysregulated CDK2 signaling leads to aberrant cell-cycle proliferation and contributes to oncogenesis.
Localization
Nucleus
Research Area
癌症
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IHC
1:1000-1:4000
IP
1:50-1:200
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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