Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-CDK6 Rabbit mAb [04C54]
抗CDK6兔单克隆抗体 [04C54]
Cat. No.
A52074
Clone No. 04C54
SynonymsCDK6, bep-1, DFT1, MTS1, BLCDF4
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
37 kDa
Observed MW
37 kDa
Clonality
Monoclonal
Clone No.
04C54
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
CDK6
Protein Name
Cyclin-dependent kinase 6
Background
CDK6 (Cyclin-dependent kinase 6) belongs to cyclin-dependent kinase family and modulates G1-phase progression as well as cell proliferation and differentiation. CDK6 is activated upon binding to Cyclin D, phosphorylates Rb tumor suppressor and liberates E2F transcription factors to push cells past G1 checkpoint toward S-phase. Beyond cell-cycle control, nuclear-localized CDK6 directly shapes transcriptional programs and regulates hematopoietic-cell differentiation. CDK6 amplification and hyper-activation are frequently observed in hematological malignancies and selected solid tumors to fuel oncogenic proliferation.
Localization
Nucleus
Research Area
癌症
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IHC
1:200-1:1000
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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