Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-Chk2 Rabbit mAb [02E16]
抗Chk2兔单克隆抗体 [02E16]
Cat. No.
A52075
Clone No. 02E16
SynonymsChk2, CHK2, CDS1-like, HUS1-related protein kinase, CHK2A
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
61 kDa
Observed MW
61 kDa
Clonality
Monoclonal
Clone No.
02E16
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
CHEK2
Protein Name
Checkpoint kinase 2
Background
Chk2 (Checkpoint kinase 2) is a serine-threonine kinase mediating DNA-damage response and cell-cycle-checkpoint activation. Upon DNA double-strand break, ATM kinase phosphorylates and activates Chk2. Activated Chk2 phosphorylates downstream substrates such as Cdc25C and p53 to arrest cell-cycle progression and provide time window for DNA repair. Chk2 triggers G1/S and G2/M checkpoint responses, leading to cell-cycle arrest, DNA repair or apoptosis. Chk2 acts as a tumor suppressor; loss-of-function mutations impair DNA-damage response and elevate tumor risk.
Localization
Nucleus
Research Area
癌症
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:2000-1:10000
IHC
1:1000-1:4000
IP
1:50-1:200
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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