Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-CHOP Rabbit mAb [01E79]
抗CHOP兔单克隆抗体 [01E79]
Cat. No.
A52076
Clone No. 01E79
SynonymsCHOP, C/EBP-homologous protein, GADD153
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
19 kDa
Observed MW
30 kDa
Clonality
Monoclonal
Clone No.
01E79
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
DDIT3
Protein Name
CCAAT/enhancer-binding protein homologous protein
Background
CHOP (C/EBP-homologous protein, DDIT3) belongs to C/EBP transcription-factor family and governs endoplasmic-reticulum-stress-dependent apoptosis. Under physiological conditions, CHOP remains barely detectable. Upon ER stress, PERK-eIF2α pathway strongly up-regulates CHOP transcription. As a transcription factor, CHOP remodels downstream gene expression, represses anti-apoptotic Bcl-2 and activates pro-apoptotic programs to trigger ER-stress-induced cell death. Sustained ER stress causes massive CHOP accumulation and cell injury, contributing to metabolic disorders, neurodegeneration and tumor drug resistance.
Localization
Nucleus
Research Area
细胞生物学
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IHC
1:100-1:400
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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